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KMID : 0043320060290121125
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Archives of Pharmacal Research
2006 Volume.29 No. 12 p.1125 ~ p.1131
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Induction of Apoptosis and Transient Increase of Phosphorylated MAPKs by Diallyl Disulfide Treatment in Human Nasopharyngeal Carcinoma CNE2 Cells
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Zhang Yi Wei
Wen Jun
Xiao Jian Bo
Talbot Simon G.
Li Gloria C.
Xu Ming
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Abstract
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This study was undertaken to elucidate the effect of diallyl disulfide (DADS), an oil-soluble organosulfur compound found in garlic, in suppressing human nasopharyngeal carcinoma cells. A potent increase (of at least 9-fold) in apoptotic cells has accompanied 1) a decrease in cell viability, 2) a increase of the fraction of S-phase cells by up to 63.8%, and 3) a transient increase of the phospho-p38 and phospho-p42/44 (phosphorylated p38 MAPK and phosphorylated p42/44 MAPK) in a time-and concentration-dependent manner. These results indicate that DADS can induce apoptosis in human nasopharyngeal carcinoma cells via, at least partly, S-phase block of the cell cycle, related to a rise in MAPK phosphorylation.
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KEYWORD
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Diallyl disulfide (DADS), Anticancer effect, Apoptosis, Cell cycle, Phosphorylated MAPKs, Human nasopharyngeal carcinoma CNE2 cells
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